N-(4-苯基噻唑-2-基)苯甲酰胺合成路线 （共 9 条）
反应条件
in pyridine Ambient temperature;
参考文献
Ramachandraiah, G.; Reddy, K. Kondal
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 808 - 810
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in dichloromethane T=20°C; 24 h;
参考文献
Li, Jing-Ran; Li, Dong-Dong; Wang, Rong-Rong; Sun, Jian; Dong, Jing-Jun; Du, Qian-Ru; Fang, Fei; Zhang, Wei-Ming; Zhu, Hai-Liang
European Journal of Medicinal Chemistry, 2014 , vol. 75, p. 438 - 447
反应条件
triethylamine in 1,4-dioxane Heating;
参考文献
Van Tilburg; Van der Klein; De Groote; Beukers; IJzerman
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 15 p. 2017 - 2019
反应条件
1: ethanol / 1 h / |Reflux 2: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 2 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Meissner, Anja; Boshoff, Helena I.; Vasan, Mahalakshmi; Duckworth, Benjamin P.; Barry III, Clifton E.; Aldrich, Courtney C.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6385 - 6397
反应条件
1: thionyl chloride / 2 h / |Reflux 2: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 2 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Zheng, Shilong; Zhong, Qiu; Jiang, Quan; Mottamal, Madhusoodanan; Zhang, Qiang; Zhu, Naijue; Burow, Matthew E.; Worthylake, Rebecca A.; Wang, Guangdi
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 191 - 196
反应条件
1.1: bromine / chloroform / 4 h / 23 °C / |Inert atmosphere 2.1: acetic acid / 3.5 h / |Inert atmosphere; |Reflux 2.2: pH 4 / |Inert atmosphere 3.1: 1-methyl-1H-imidazole / dichloromethane / 18 h / 23 °C / |Inert atmosphere View Scheme
参考文献
Meissner, Anja; Boshoff, Helena I.; Vasan, Mahalakshmi; Duckworth, Benjamin P.; Barry III, Clifton E.; Aldrich, Courtney C.
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6385 - 6397
反应条件
hydrogen bromide in N,N-dimethyl-formamide Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Chakrabarti, Jiban K.; Smith, Colin W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1169 - 1171
参考文献
Selim,M. et al.
Bulletin de la Societe Chimique de France, 1966 , p. 3403 - 3407
反应条件
triethylamine in N,N-dimethyl-formamide Ambient temperature;
参考文献
Chakrabarti, Jiban K.; Smith, Colin W.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 1169 - 1171
