1.1: NaOEt / ethanol / 0.5 h 1.2: 1.25 g / ethanol / Heating 2.1: 540 mg / aq. HCl / Heating 3.1: 78 percent / NaHCO3 / H2O / 0.17 h / pH 8 4.1: 43 percent / aq. NaOH; CoCl2*6H2O; acylase I from Aspergillus melleus / aq. phosphate buffer / 39 °C / pH 7.2 View Scheme

(i) CuI, MeLi, THF, Et2O, (ii) /BRN= 1752063/; Multistep reaction;

1: 1.) Mg, 2.) CuI, 1.5M CH3Li / 1.) THF, 2.) THF, ether, -78 deg C, 1 h, -78 to 10 deg C, 3.) THF, ether, -78 deg C, 1 h, room temp., 20 h 2: 95 percent / LiAlH4 / tetrahydrofuran View Scheme

1.1: sodium / ethanol / 0.5 h 1.2: ethanol / Heating 1.3: 71 percent / HCl / H2O / Heating 2.1: 100 percent / thionyl chloride / -20 °C View Scheme

1.1: NaOEt / ethanol / 0.5 h 1.2: 1.25 g / ethanol / Heating 2.1: 540 mg / aq. HCl / Heating View Scheme

1.1: NaOEt / ethanol / 0.5 h 1.2: 1.25 g / ethanol / Heating 2.1: 540 mg / aq. HCl / Heating 3.1: 78 percent / NaHCO3 / H2O / 0.17 h / pH 8 4.1: 45 percent / aq. NaOH; CoCl2*6H2O; acylase I from Aspergillus melleus / aq. phosphate buffer / 39 °C / pH 7.2 5.1: 84 percent / aq. HCl / Heating View Scheme

copper(l) iodide; methyllithium; magnesium 1.) THF, 2.) THF, ether, -78 deg C, 1 h, -78 to 10 deg C, 3.) THF, ether, -78 deg C, 1 h, room temp., 20 h; Yield given. Multistep reaction. Yields of byproduct given;