7-苯基-6,8-二噁螺[3.5]壬烷-2,2-二羧酸-2,2-二乙酯合成路线 （共 5 条）
反应条件
1: diethyl malonate With sodium hydride in N,N-dimethyl-formamide 2: 2-phenyl-5,5-di(bromomethyl)-1,3-dioxane in N,N-dimethyl-formamide T=140°C; 4 h;
参考文献
GLAXO GROUP LIMITED
Patent: WO2008/119720 A1, 2008 ;
Location in patent: Page/Page column 48 ;
WO 2008/119720 A1
反应条件
1: 81 percent / pyridine / 10 h / Ambient temperature 2: 1.) NaH, 2.) KI / 1.) DMF, 70 deg C, 30 min, 2.) DMF, 140 deg C, 12 h View Scheme
参考文献
Pecquet, Pascal; Huet, Francois; Legraverend, Michel; Bisagni, Emile
Heterocycles, 1992 , vol. 34, # 4 p. 739 - 745
反应条件
sodium hydride; potassium iodide 1.) DMF, 70 deg C, 30 min, 2.) DMF, 140 deg C, 12 h; Yield given. Multistep reaction;
参考文献
Pecquet, Pascal; Huet, Francois; Legraverend, Michel; Bisagni, Emile
Heterocycles, 1992 , vol. 34, # 4 p. 739 - 745
反应条件
1: 92 percent / KOH 2: 94 percent / HNO3 3: 2.) acetyl chloride / 1.) 185 deg C, from 60 Torr to 20 Torr 4: 91 percent / Et3N / tetrahydrofuran / 10 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 34, # 4 p. 739 - 745
反应条件
1: 92 percent / KOH
2: 94 percent / HNO3
View Scheme
参考文献
Pecquet, Pascal; Huet, Francois; Legraverend, Michel; Bisagni, Emile
Heterocycles, 1992 , vol. 34, # 4 p. 739 - 745
