1: (Tri-iso-propylsilyl)acetylene With n-butyllithium in tetrahydrofuran; hexane T=-40°C; Metallation; 2: 3-triisopropyl-α,β-acetylenic aldehyde in tetrahydrofuran; hexane T=-40°C; Addition; 0.5 h; Further stages.;

1: (Tri-iso-propylsilyl)acetylene With n-butyllithium in tetrahydrofuran; hexane T=-30°C; 0.25 h; Inert atmosphere; 2: formic acid ethyl ester in tetrahydrofuran; hexane T=-78 - -30°C; 2 h; Inert atmosphere; 3: With hydrogenchloride; ammonium chloride in tetrahydrofuran; hexane; water

1.1: n-butyllithium; DMF / tetrahydrofuran / 0.5 h / 20 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / -40 °C 2.2: 97 percent / tetrahydrofuran; hexane / 0.5 h / -40 °C View Scheme

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1: (Tri-iso-propylsilyl)acetylene With potassium dihydrogenphosphate; n-butyllithium Metallation; 2: N,N-dimethyl-formamide Addition; 3: triisopropylsilyl lithium acetylide Alkylation; Further stages.;