(2S,3s)-1-(2-甲基氨基-2-苯基-乙基)-吡咯烷-3-醇合成路线 （共 5 条）
反应条件
lithium aluminium tetrahydride in toluene T=0 - 80°C; 18 h;
参考文献
Chemical communications (Cambridge, England), , # 15 p. 1644 - 1645
反应条件
1: 90 percent / DCC; HOBt / CH2Cl2 2: 70 percent / LiAlH4 / toluene / 18 h / 0 - 80 °C View Scheme
参考文献
Chemical communications (Cambridge, England), , # 15 p. 1644 - 1645
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 3 h; Heating / reflux;
参考文献
US6344566 B1, ;
Example 4 ;
反应条件
1.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 1 h / -10 °C 1.2: 1 h / -10 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / |Inert atmosphere; |Reflux View Scheme
反应条件
1.1: sodium hydroxide / water / 4 h / 5 - 20 °C 1.2: pH 3 2.1: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane / 1 h / -10 °C 2.2: 1 h / -10 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / |Inert atmosphere; |Reflux View Scheme
