1-苯基-3-三氟甲基-1H-吡唑-4-羧酸合成路线 （共 11 条）
反应条件
lithium hydroxide hydrate in tetrahydrofuran T=70°C; pH=5; 2 h;
参考文献
Wu, Zhibing; Hu, Deyu; Kuang, Jiqing; Cai, Hua; Wu, Shixi; Xue, Wei
Molecules, 2012 , vol. 17, # 12 p. 14205 - 14218
反应条件
pyridine; sodium hydroxide; copper diacetate in ethanol (100 mL)-THF; N,N-dimethyl-formamide
参考文献
EP1845081 A1, ;
EP 1845081 A1
反应条件
potassium hydroxide in ethanol 4 h; Ambient temperature;
参考文献
Okada, Etsuji; Masuda, Ryoichi; Hojo, Masaru
Heterocycles, 1992 , vol. 34, # 4 p. 791 - 798
反应条件
1: With pyridine; copper diacetate in N,N-dimethyl-formamide T=20°C; 24 h; 2: With water; sodium hydroxide in tetrahydrofuran; ethanol T=20 - 50°C; 8 h; Heating / reflux; 3: With hydrogenchloride; water
参考文献
WO2006/82952 A1, ;
Page/Page column 175-176 ;
反应条件
1: 12 percent / acetonitrile / 1 h / Ambient temperature 2: 100 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 34, # 4 p. 791 - 798
反应条件
1: copper diacetate; pyridine / N,N-dimethyl-formamide / 24 h / 20 °C 2: lithium hydroxide hydrate / tetrahydrofuran / 2 h / 70 °C / pH 5 View Scheme
参考文献
Molecules, , vol. 17, # 12 p. 14205 - 14218
反应条件
1: hydrazine hydrate / methanol / 3 h / 80 °C 2: copper diacetate; pyridine / N,N-dimethyl-formamide / 24 h / 20 °C 3: lithium hydroxide hydrate / tetrahydrofuran / 2 h / 70 °C / pH 5 View Scheme
参考文献
Molecules, , vol. 17, # 12 p. 14205 - 14218
反应条件
1: 72 percent / CF3COOH, H2O / CHCl3 / 3 h / Ambient temperature 2: 100 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 34, # 4 p. 791 - 798
反应条件
1: 5 percent / acetonitrile / 1 h / Ambient temperature 2: 100 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 34, # 4 p. 791 - 798
反应条件
1: 20 percent / acetonitrile / 1 h / Ambient temperature 2: 100 percent / sat. aq. KOH / ethanol / 4 h / Ambient temperature View Scheme
参考文献
Heterocycles, , vol. 34, # 4 p. 791 - 798
