N-Boc-4-哌啶甲酸乙酯合成路线 （共 67 条）
反应条件
triethylamine in dichloromethane
参考文献
Chaturvedula, Prasad V.; Chen, Ling; Civiello, Rita; Conway, Charles Mark; Degnan, Andrew P.; Dubowchik, Gene M.; Han, Xiaojun; J. Jiang, Xiang Jun; Karageorge, George N.; Luo, Guanglin; Macor, John E.; Poindexter, Graham; Tora, George; Vig, Shikha
Patent: US2004/204397 A1, 2004 ;
US 20040204397 A1
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
FAB PHARMA SAS; GERUSZ, Vincent; ESCAICH, Sonia; OXOBY, Mayalen; DENIS, Alexis
Patent: WO2011/61214 A1, 2011 ;
Location in patent: Page/Page column 111-112 ;
WO 2011/061214 A1
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in tetrahydrofuran T=0°C; 1 h;
参考文献
WO2004/14910 A1, ;
Page 32-33 ;
WO 2004/014910 A1
参考文献
Merrell Dow Pharmaceuticals, Inc.
Patent: US5420271 A1, 1995 ;
反应条件
triethylamine in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Jansen, Michaela; Rabe, Holger; Strehle, Axelle; Dieler, Sandra; Debus, Fabian; Dannhardt, Gerd; Akabas, Myles H.; Lueddens, Hartmut
Journal of Medicinal Chemistry, 2008 , vol. 51, # 15 p. 4430 - 4448
反应条件
triethylamine in dichloromethane
反应条件
in water; ethyl acetate
参考文献
US2004/48881 A1, ;
US 20040048881 A1
反应条件
1: ethyl 1-tert-butyloxycarbonyl-4-piperidinecarboxylate With lithium diisopropyl amide in tetrahydrofuran T=-78 - -40°C; 2: carbon dioxide in tetrahydrofuran T=-78 - 20°C;
参考文献
EP2305660 A1, ;
Page/Page column 33-34 ;
反应条件
1: 80 percent / benzene; tetrahydrofuran / 1 h / 20 °C 2: 98 percent / trifluoroacetic acid / CH2Cl2 / 16 h / 20 °C View Scheme
参考文献
Lee, Jeewoo; Kang, Sang-Uk; Lim, Ju-Ok; Choi, Hyun-Kyung; Jin, Mi-Kyung; Toth, Attila; Pearce, Larry V.; Tran, Richard; Wang, Yun; Szabo, Tamas; Blumberg, Peter M.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 2 p. 371 - 385
