N-Boc-4-哌啶甲酸乙酯合成路线

参考文献

ABIDE THERAPEUTICS; THE SCRIPPS RESEARCH INSTITUTE; CISAR, Justin, S.; GRICE, Chery, A.; JONES, Todd, K.; NIPHAKIS, Micah, J.; CHANG, Jae, Won; LUM, Kenneth, M.; CRAVATT, Benjamin, F.
Patent: WO2013/103973 A1, 2013 ;

142851-03-4N-Boc-4-哌啶甲酸乙酯

154348-08-01-氧代-2-噁-8-氮杂螺[4.5]癸烷-8-羧酸叔丁酯

参考文献

Cooper, Laura C.; Carlson, Emma J.; Castro, Jose L.; Chicchi, Gary G.; Dinnell, Kevin; Di Salvo, Jerry; Elliott, Jason M.; Hollingworth, Gregory J.; Kurtz, Marc M.; Ridgill, Mark P.; Rycroft, Wayne; Tsao, Kwei-Lan; Swain, Christopher J.
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 13 p. 1759 - 1762

75-21-8环氧乙烷+

142851-03-4N-Boc-4-哌啶甲酸乙酯

154348-08-01-氧代-2-噁-8-氮杂螺[4.5]癸烷-8-羧酸叔丁酯

参考文献

Cignarella; Villa; Barlocco
Farmaco, 1993 , vol. 48, # 10 p. 1439 - 1445

142851-03-4N-Boc-4-哌啶甲酸乙酯

297172-16-84-羟基甲基-4-甲基-哌啶

参考文献

Sumiyoshi, Takaaki; Enomoto, Takeshi; Takai, Kentaro; Takahashi, Yoko; Konishi, Yasuko; Uruno, Yoshiharu; Tojo, Kengo; Suwa, Atsushi; Matsuda, Harumi; Nakako, Tomokazu; Sakai, Mutsuko; Kitamura, Atsushi; Uematsu, Yasuaki; Kiyoshi, Akihiko
ACS Medicinal Chemistry Letters, 2013 , vol. 4, # 2 p. 244 - 248

142851-03-4N-Boc-4-哌啶甲酸乙酯+

74-88-4甲基碘

189442-87-3N-Boc-4-甲基-4-哌啶甲酸乙酯

参考文献

ARRAY BIOPHARMA INC.
Patent: WO2008/121687 A2, 2008 ;
Location in patent: Page/Page column 43; 89; 94 ;
WO 2008/121687 A2

75-11-6二碘甲烷+

142851-03-4N-Boc-4-哌啶甲酸乙酯

213013-98-04-乙基4-(碘甲基)哌啶-1,4-二羧酸-1-叔丁酯

参考文献

Becker, Daniel P.; Villamil, Clara I.; Barta, Thomas E.; Bedell, Louis J.; Boehm, Terri L.; DeCrescenzo, Gary A.; Freskos, John N.; Getman, Daniel P.; Hockerman, Susan; Heintz, Robert; Howard, Susan Carol; Li, Madeleine H.; McDonald, Joseph J.; Carron, Chris P.; Funckes-Shippy, Chris L.; Mehta, Pramod P.; Munie, Grace E.; Swearingen, Craig A.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 21 p. 6713 - 6730

213013-98-04-乙基4-(碘甲基)哌啶-1,4-二羧酸-1-叔丁酯

参考文献

Japan Tobacco Inc.
Patent: US6562828 B1, 2003 ;
US 6562828 B1

142851-03-4N-Boc-4-哌啶甲酸乙酯

188792-67-81-Boc-4-乙基-4-哌啶甲酸

参考文献

HETERO RESEARCH FOUNDATION
Patent: US2011/15196 A1, 2011 ;

142851-03-4N-Boc-4-哌啶甲酸乙酯

189321-63-91-Boc-4-甲基-4-哌啶甲酸

参考文献

Jiang, Xiao-Hua; Song, Yan-Li; Long, Ya-Qiu
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3675 - 3678

142851-03-4N-Boc-4-哌啶甲酸乙酯