1: 53 percent / 4 N HCl / dioxane; diethyl ether / 0.83 h 2: 66 percent / diisopropylethylamine (DIEA) / CH2Cl2 / 16 h 3: 69 percent / diborane / tetrahydrofuran / 18 h / Heating View Scheme

<b>Multi-step reaction with 3 steps<br /> </b>1: 89 percent / aq. NaOH / 2-methyl-propan-2-ol / 12 h<br />2: 69 percent / dicyclohexylcarbodimide (DCC) / CH₂Cl₂ / 12 h / 0 &deg;C<br />3: 66 percent / diisopropylethylamine (DIEA) / CH₂Cl₂ / 6 h<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 89 percent / aq. NaOH / 2-methyl-propan-2-ol / 12 h<br />2: 69 percent / dicyclohexylcarbodimide (DCC) / CH₂Cl₂ / 12 h / 0 &deg;C<br />3: 66 percent / diisopropylethylamine (DIEA) / CH₂Cl₂ / 6 h<br /> <br /> &nbsp;