N-(3,4-二甲氧基苯乙基)甲酰胺合成路线 （共 25 条）
反应条件
1.1: 14.48 g / phosphoryl chloride / toluene / 1 h / Heating 2.1: 59.7 percent / bromophenol blue; conc. hydrochloric acid / methanol / 0 - 20 °C 3.1: KHMDS / tetrahydrofuran / 3 h / -78 °C 3.2: 557.6 mg / aq. NiCl2 / methanol / 20 °C 4.1: triethylamine; formic acid / (R,R)-Noyori's catalyst / dimethylformamide / 4.5 h / 20 °C View Scheme
参考文献
Werner, Frank; Blank, Nancy; Opatz, Till
European Journal of Organic Chemistry, 2007 , # 23 p. 3911 - 3915
反应条件
sodium tetrahydroborate; boron trifluoride diethyl etherate in tetrahydrofuran 1) room temperature, 1 h; 2) reflux, 3 h;
参考文献
Sindelar, Karel; Dobrovsky, Karel; Krejci, Ivan; Polivka, Zdenek
Collection of Czechoslovak Chemical Communications, 1995 , vol. 60, # 5 p. 894 - 902
反应条件
1: trichlorophosphate / toluene / 2.5 h / 110 °C / Inert atmosphere 2: potassium borohydride; diethylamine / methanol / 24 h / 20 °C View Scheme
参考文献
Zou, Zhi-Hong; Lan, Xiao-Bu; Tang, Chun-Lei; Zhu, Xiao-Yun; Liu, Bao-Min; Qian, Hai; Huang, Wen-Long; Li, Yun-Man
Medicinal Chemistry, 2012 , vol. 8, # 4 p. 711 - 716
反应条件
PPA in dichloromethane T=50°C; 2 h;
参考文献
Ivanov, Iliyan; Nikolova, Stoyanka; Statkova-Abeghe, Stela; Angelov, Plamen
Heterocycles, 2006 , vol. 68, # 2 p. 387 - 393
反应条件
1: 59 percent / polyphosphoric acid / CH2Cl2 / 2 h / 50 °C 2: 65 percent / pTsOH / 1,2-dichloro-ethane / 0.5 h / Heating 3: polyphophoric acid / 80 - 100 °C View Scheme
参考文献
Ivanov, Iliyan; Nikolova, Stoyanka; Statkova-Abeghe, Stela; Angelov, Plamen
Heterocycles, 2006 , vol. 68, # 2 p. 387 - 393
反应条件
trichlorophosphate in toluene
参考文献
Hillard, Russel L.; Parnell, Carol A.; Vollhardt, K. Peter C.
Tetrahedron, 1983 , vol. 39, # 6 p. 905 - 912
参考文献
Spaeth; Epstein
Chemische Berichte, 1926 , vol. 59, p. 2794
Full Text Show Details
Spaeth; Polgar
Monatshefte fuer Chemie, 1929 , vol. 51, p. 199
反应条件
1.1: 14.48 g / phosphoryl chloride / toluene / 1 h / Heating 2.1: 59.7 percent / bromophenol blue; conc. hydrochloric acid / methanol / 0 - 20 °C 3.1: KHMDS / tetrahydrofuran / 3 h / -78 °C 3.2: 557.6 mg / aq. NiCl2 / methanol / 20 °C View Scheme
参考文献
Werner, Frank; Blank, Nancy; Opatz, Till
European Journal of Organic Chemistry, 2007 , # 23 p. 3911 - 3915
反应条件
1: 76 percent / POCl3 / toluene / 1 h / 85 °C 2: 85 percent / NaHCO3 / CH2Cl2; H2O / 1.5 h / 20 °C View Scheme
参考文献
Reimann, Eberhard; Grasberger, Fritz
Monatshefte fur Chemie, 2005 , vol. 136, # 2 p. 193 - 209
反应条件
1: 14.48 g / phosphoryl chloride / toluene / 1 h / Heating 2: 59.7 percent / bromophenol blue; conc. hydrochloric acid / methanol / 0 - 20 °C View Scheme
参考文献
Orejarena Pacheco, Julio Cesar; Lahm, Guenther; Opatz, Till
Journal of Organic Chemistry, 2013 , vol. 78, # 10 p. 4985 - 4992
