Boc-D-3,3-二苯基丙氨酸合成路线 （共 15 条）
反应条件
T=0°C; Jones oxidation;
参考文献
Kanemasa; Adachi; Yamamoto; Wada
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 3 p. 681 - 687
反应条件
N-ethyl-N,N-diisopropylamine in methanol
参考文献
Chen; Beylin; Marlatt; Leja; Goel
Tetrahedron Letters, 1992 , vol. 33, # 23 p. 3293 - 3296
反应条件
1: iPr2NEt / tetrahydrofuran / 1 h / -78 to 0 deg C 2: 1) n-BuLi / 1) THF, -78 deg C, 2) -78 to 0 deg C 3: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 2) THF, -78 deg C, 2 min 4: 99 percent / LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C 5: 77 percent / HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 6: 81 percent / iPr2NEt / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 23 p. 3293 - 3296
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 2) -78 to 0 deg C 2: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 2) THF, -78 deg C, 2 min 3: 99 percent / LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C 4: 77 percent / HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 5: 81 percent / iPr2NEt / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 23 p. 3293 - 3296
反应条件
1: 1) n-BuLi / 1) THF, -78 deg C, 2) -78 to 0 deg C 2: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 2) THF, -78 deg C, 2 min 3: 99 percent / LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C 4: 77 percent / HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 5: 81 percent / iPr2NEt / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 23 p. 3293 - 3296
反应条件
1: 77 percent / HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 2: 81 percent / iPr2NEt / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 23 p. 3293 - 3296
反应条件
1: 1) KHMDS, 2) trisyl azide / 1) THF, -78 deg C, 2) THF, -78 deg C, 2 min 2: 99 percent / LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C 3: 77 percent / HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 4: 81 percent / iPr2NEt / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 23 p. 3293 - 3296
反应条件
1: 99 percent / LiOH*H2O, 30percent aq. H2O2 / tetrahydrofuran; H2O / 1 h / 0 °C 2: 77 percent / HCl, H2 / 10percent Pd/C / tetrahydrofuran / 20 h / 2585.7 Torr 3: 81 percent / iPr2NEt / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 23 p. 3293 - 3296
反应条件
1.1: H2 / 20 percent Pd(OH)2/C / formic acid / 6 h / 20 °C / 5171.48 Torr 1.2: 78 percent / 1M aq. NaOH / ethyl acetate / 4 h 2.1: 88 percent / Jones reagent / acetone / 4 h / 0 °C View Scheme
参考文献
Heterocycles, , vol. 57, # 6 p. 1143 - 1148
反应条件
1.1: 91 percent / CH2Cl2 / 4 h / 20 °C 2.1: 96 percent / KOH / ethanol / 2 h / 20 °C 3.1: H2 / 20 percent Pd(OH)2/C / formic acid / 6 h / 20 °C / 5171.48 Torr 3.2: 78 percent / 1M aq. NaOH / ethyl acetate / 4 h 4.1: 88 percent / Jones reagent / acetone / 4 h / 0 °C View Scheme
参考文献
Heterocycles, , vol. 57, # 6 p. 1143 - 1148
