反应条件
1.1: lithium diisopropyl amide / hexane; tetrahydrofuran / 0.5 h / -25 °C / |Inert atmosphere
1.2: -25 - 10 °C / |Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 23 h / |Inert atmosphere; |Reflux
3.1: n-butyllithium / hexane; tetrahydrofuran / 1.25 h / 0 - 20 °C / |Inert atmosphere
3.2: 0.02 h / -12 - 18 °C / |Inert atmosphere
3.3: 20 h / 95 °C / |Inert atmosphere
View Scheme
参考文献
Sandham, David A.; Arnold, Nicola; Aschauer, Heinrich; Bala, Kamlesh; Barker, Lucy; Brown, Lyndon; Brown, Zarin; Budd, David; Cox, Brian; Docx, Cerys; Dubois, Gerald; Duggan, Nicholas; England, Karen; Everatt, Brian; Furegati, Marcus; Hall, Edward; Kalthoff, Frank; King, Anna; Leblanc, Catherine J.; Manini, Jodie; Meingassner, Josef; Profit, Rachael; Schmidt, Alfred; Simmons, Jennifer; Sohal, Bindi; Stringer, Rowan; Thomas, Matthew; Turner, Katharine L.; Walker, Christoph; Watson, Simon J.; Westwick, John; Willis, Jennifer; Williams, Gareth; Wilson, Caroline
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 21 p. 6582 - 6591