(R)-(+)-2-三氟甲基环氧乙烷合成路线 （共 8 条）
反应条件
1: With bis[(1S,2R,3S,5S)-pinan-3-yl]chloroborane in diethyl ether T=-4 - 5°C; 72 h; 2: Further stages.;
参考文献
Durley; Grapperhaus; Massa; Mischke; Parnas; Fobian; Rath; Honda; Zeng; Connolly; Heuvelman; Witherbee; Glenn; Krul; Smith; Sikorski
Journal of Medicinal Chemistry, 2000 , vol. 43, # 24 p. 4575 - 4578
反应条件
(S,S)-[1,2-cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]cobaltIII*OAc; water T=0 - 20°C;
参考文献
Schaus, Scott E.; Brandes, Bridget D.; Larrow, Jay F.; Tokunaga, Makoto; Hansen, Karl B.; Gould, Alexandra E.; Furrow, Michael E.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2002 , vol. 124, # 7 p. 1307 - 1315
反应条件
C64H74Cl2Co2N4O4; bis(triphenylphosphoranylidene)-ammonium acetate in toluene T=0°C; 0.0333333 h; Product distribution / selectivity;
参考文献
CORNELL RESEARCH FOUNDATION, INC.
Patent: WO2009/26261 A2, 2009 ;
Location in patent: Page/Page column 69; 77-78 ;
反应条件
sodium hydroxide T=95 - 100°C; Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ramachandran, P. Veeraraghavan; Gong, Baoqing; Brown, Herbert C.
Journal of Organic Chemistry, 1995 , vol. 60, # 1 p. 41 - 46
反应条件
(S,S)-[1,2-cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]cobaltIII*OAc; water T=0 - 20°C;
参考文献
Schaus, Scott E.; Brandes, Bridget D.; Larrow, Jay F.; Tokunaga, Makoto; Hansen, Karl B.; Gould, Alexandra E.; Furrow, Michael E.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2002 , vol. 124, # 7 p. 1307 - 1315
反应条件
(S,S)-[1,2-cyclohexanediamino-N,N'-bis(3,5-di-t-butylsalicylidene)]cobaltIII*OAc; water T=0 - 20°C;
参考文献
Schaus, Scott E.; Brandes, Bridget D.; Larrow, Jay F.; Tokunaga, Makoto; Hansen, Karl B.; Gould, Alexandra E.; Furrow, Michael E.; Jacobsen, Eric N.
Journal of the American Chemical Society, 2002 , vol. 124, # 7 p. 1307 - 1315
反应条件
water; [(1-SS)-(Dibenzoyl-DTA)] T=5 - 20°C; Resolution of racemate; Product distribution / selectivity;
参考文献
WO2008/153280 A1, ;
Page/Page column 39 ;
反应条件
sodium hydroxide; B-chloro-diisopinocampheylborane 1.) Et2O, -25 deg C, 96 h, 2.) 95-100 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 60, # 1 p. 41 - 46
