4-氨基-2-氟-5-硝基苯甲腈合成路线 (共 4 条)
反应条件
ammonia in ethanol T=20°C;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; CIANCI, Christopher, W.; GERRITZ, Samuel; LI, Guo; PEARCE, Bradley, C.; PENDRI, Annapurna; SHI, Shuhao; ZHAI, Weixu; ZHU, Shirong
Patent: WO2012/33736 A1, 2012 ;
Location in patent: Page/Page column 60 ;
参考文献
Axys Pharmaceuticals, Inc.
Patent: US6150379 A1, 2000 ;
反应条件
1: KNO3; 18 N H2SO4 2: NH3 View Scheme
参考文献
Ohmori; Sakamoto; Kubota; Shimizu-Sasamata; Okada; Kawasaki; Hidaka; Togami; Furuya; Murase
Journal of Medicinal Chemistry, 1994 , vol. 37, # 4 p. 467 - 475
反应条件
hydrogen; palladium on activated charcoal P=760 Torr;
参考文献
Axys Pharmaceuticals, Inc.
Patent: US6150379 A1, 2000 ;