2-(2-甲基苯氧甲基)苯基草酸甲酯合成路线 （共 9 条）
反应条件
1: 2-(2-methylphenoxymethyl)benzoyl cyanide With hydrogenchloride in anhydrous xylene T=-5 - 0°C; 2 h; 2: methanol With sulfuric acid in anhydrous xylene T=15 - 65°C; 13 h;
参考文献
WO2013/144924 A1, ;
Page/Page column 28; 35; 36 ;
反应条件
hydrogenchloride; acetic anhydride in methanol; chloroform-d1; dichloromethane; toluene
反应条件
hydrogenchloride; acetic anhydride in methanol; water
反应条件
tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=0°C; Substitution; 4 h;
参考文献
Rossi, Renzo; Carpita, Adriano; Pazzi, Piergiorgio; Mannina, Luisa; Valensin, Daniela
Tetrahedron, 1999 , vol. 55, # 37 p. 11343 - 11364
反应条件
1.1: tetrabutylammomium bromide / anhydrous xylene; water / 6 h / 10 - 20 °C 2.1: hydrogenchloride / anhydrous xylene / 2 h / -5 - 0 °C 2.2: 13 h / 15 - 65 °C View Scheme
反应条件
1.1: thionyl chloride / anhydrous xylene; N,N-dimethyl-formamide / 8 h / 50 °C 2.1: tetrabutylammomium bromide / anhydrous xylene; water / 6 h / 10 - 20 °C 3.1: hydrogenchloride / anhydrous xylene / 2 h / -5 - 0 °C 3.2: 13 h / 15 - 65 °C View Scheme
反应条件
hydrogenchloride in methanol; dichloromethane
参考文献
BASF Aktiengesellschaft
Patent: US5221762 A1, 1993 ;
反应条件
in pyridine T=20°C; Condensation; 17.5 h;
参考文献
Tetrahedron, , vol. 55, # 37 p. 11343 - 11364
反应条件
1: 28 percent / pyridine / 17.5 h / 20 °C 2: I2 / benzene / 120 h / 63 °C / UV-irradiation View Scheme
参考文献
Rossi, Renzo; Carpita, Adriano; Pazzi, Piergiorgio; Mannina, Luisa; Valensin, Daniela
Tetrahedron, 1999 , vol. 55, # 37 p. 11343 - 11364
