1.1: triethylamine; diphenyl phosphoryl azide / toluene / 20 - 90 °C / |Inert atmosphere; |Schlenk technique 2.1: toluene / |Reflux; |Inert atmosphere; |Schlenk technique 3.1: lithium hydroxide hydrate; dihydrogen peroxide / water; tetrahydrofuran / 3 h / 20 °C / |Inert atmosphere; |Schlenk technique 3.2: 0 °C / |Inert atmosphere; |Schlenk technique 4.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C / 11251.1 Torr View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '23761990', constants.ctx, '0')">N-((1R,2R)-2-(dimethylamino)-1-(4-nitrophenyl)-3-(trityloxy)propyl)-3,5-bis(trifluoromethyl)benzene-sulfonamide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730942', constants.ctx, '0')">tert-butyl methyl ether</a> <br />T=-20&deg;C;&nbsp;&nbsp;Inert atmosphereSchlenk technique;&nbsp;&nbsp;enantioselective reaction;&nbsp;<br /> &nbsp;