1: acetic acid 2: (enzymatic racemate resolution) View Scheme

1: triethylamine / dichloromethane / 18 h / 20 °C 2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C 3: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C 4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C 5: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 6 h / 20 °C View Scheme

1: With sodium hydroxide in water 2: With hydrogenchloride in water; isopropyl alcohol Product distribution / selectivity;

1: aq. NaOH / dioxane / 20 °C 2: NEt3 / tetrahydrofuran / -10 °C 3: 66 percent / NaBH4 / H2O / 0 °C View Scheme

triethylamine in 1,4-dioxane; water T=0 - 20°C;

triethylamine in water; N,N-dimethyl-formamide T=40°C; 24 h;