8-氧代-5-氮杂螺[2.5]辛烷-5-羧酸叔丁酯合成路线 （共 2 条）
反应条件
1: tert-butyl 4-oxo-piperidine-1-carboxylate With potassium tert-butylate in tert-butyl alcohol 0.0833333 h; Inert atmosphere; 2: 2-chloroethyl-dimethylsulphonium iodide in tert-butyl alcohol T=20°C; 18.16 h;
参考文献
SCHERING CORPORATION; BOYLE, Craig, D.; LANKIN, Claire, M.; SHAH, Unmesh, G.; GREENLEE, William, J.; CHACKALAMANNIL, Samuel
Patent: WO2010/114957 A1, 2010 ;
Location in patent: Page/Page column 64-65 ;
WO 2010/114957 A1
反应条件
1: tert-butyl 4-oxo-piperidine-1-carboxylate With potassium tert-butylate in tert-butyl alcohol 0.0833333 h; 2: 2-chloroethyldimethylsulfonium iodide in tert-butyl alcohol
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2005/40120 A1, 2005 ;
Location in patent: Page/Page column 24-25 ;
WO 2005/040120 A1
