3,4-(异亚丙基二氧基)莽草酸甲酯乙酸酯合成路线 （共 2 条）
反应条件
toluene-4-sulfonic acid in methanol Heating;
参考文献
Johnson, Carl R.; Adams, Joseph P.; Collins, Mark A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993 , # 1 p. 1 - 2
反应条件
1: 94 percent / aq. HOAc / tetrahydrofuran / 6 h / 70 °C 2: 1.) dibutyltin oxide / 1.) benzene, reflux, 1 h, 2.) DMF, 30 min 3: 100 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 1 h / 50 °C 4: 89 percent / 80percent aq. HOAc / 0.25 h 5: tetrazole / CH2Cl2 / 2 h / Ambient temperature 6: 0.304 g / m-CPBA / CH2Cl2 / 2 h / -40 °C 7: 80 percent / bromotrimethylsilane / CH2Cl2 / 1 h / 0 °C 8: 99 percent / 1 N NaOH / 3 h / 0 °C View Scheme
参考文献
Chahoua, Latifa; Baltas, Michel; Gorrichon, Liliane; Tisnes, Pierre; Zedde, Chantal
Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5798 - 5801
