(R)-5-溴-3-(1-甲基-2-吡咯烷基甲基)-1H-吲哚合成路线 （共 20 条）
反应条件
sodium carbonate in water; toluene T=30 - 35°C; pH=7.8; 0.5 h;
参考文献
KANSAL, Vinod Kumar; MISTRY, Dhirenkumar N.; PATEL, Rakesh Ravjibhai; PANDEY, Saurabh
Patent: US2009/299077 A1, 2009 ;
Location in patent: Page/Page column 9-10 ;
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in tetrahydrofuran; toluene T=30 - 50°C; 1.66667 - 2 h; 2: With sodium hydroxide; water in tetrahydrofuran; toluene T=5 - 25°C; Product distribution / selectivity;
参考文献
Bednar, Roman; Simo, Ondrej; Blatny, Pavel
Patent: US2008/319205 A1, 2008 ;
Location in patent: Page/Page column 4-5 ;
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in tert-butyl methyl ether; toluene T=30 - 48°C; 3.16667 h; 2: With sodium hydroxide; water in tert-butyl methyl ether; toluene T=15 - 20°C; 0.5 h; Product distribution / selectivity;
参考文献
Bednar, Roman; Simo, Ondrej; Blatny, Pavel
Patent: US2008/319205 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in toluene T=30 - 48°C; 2.66667 h; 2: With sodium hydroxide; water in toluene T=15 - 20°C; 1 h; Product distribution / selectivity;
参考文献
Bednar, Roman; Simo, Ondrej; Blatny, Pavel
Patent: US2008/319205 A1, 2008 ;
Location in patent: Page/Page column 5 ;
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in toluene T=10 - 50°C; Inert atmosphereDarkness; 2: With sodium hydroxide in water; toluene T=0 - 35°C; pH=12 - 13; Product distribution / selectivity;
参考文献
WO2012/4811 A1, ;
Page/Page column 29-30 ;
反应条件
1.1: oxalyl dichloride / N,N-dimethyl-formamide; toluene / 2.5 h / 20 - 25 °C 2.1: methyl-magnesium chloride / tert-butyl methyl ether; tetrahydrofuran / 0.75 h / 20 °C 2.2: 0.5 h / 3 - 20 °C 3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 60 °C / Reflux View Scheme
反应条件
1.1: methyl-magnesium chloride / tert-butyl methyl ether; tetrahydrofuran / 0.75 h / 20 °C 1.2: 0.5 h / 3 - 20 °C 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 60 °C / Reflux View Scheme
反应条件
1.1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 3 h / Reflux 2.1: ethylmagnesium bromide; zinc(II) chloride / dichloromethane; tetrahydrofuran / 5 - 30 °C 2.2: -10 - 25 °C 3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness 3.2: 0 - 35 °C / pH 12 - 13 View Scheme
反应条件
1.1: ethylmagnesium bromide; zinc(II) chloride / dichloromethane; tetrahydrofuran / 5 - 30 °C 1.2: -10 - 25 °C 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 10 - 50 °C / Inert atmosphere; Darkness 2.2: 0 - 35 °C / pH 12 - 13 View Scheme
反应条件
1: With N,N-dimethyl-formamide T=95 - 100°C; 2: With ammonia in water T=0 - 5°C; pH=8 - 9; Product distribution / selectivity;
参考文献
Kumar, U. Sampath; Sankar, V. Ravi; Rao, M. Malleswara; Jaganathan; Buchi Reddy
Organic Process Research and Development, 2012 , vol. 16, # 12 p. 1917 - 1920
