1-(4-溴苯基)环戊烷甲腈合成路线 （共 3 条）
反应条件
sodium hydroxide 1.) 45 deg C, 2.) 120 deg C, 12 h; Yield given. Multistep reaction;
参考文献
Pharmaceutical Chemistry Journal, , vol. 26, # 2 p. 169 - 173
Khimiko-Farmatsevticheskii Zhurnal, , vol. 26, # 2 p. 54 - 56
反应条件
1: 60.4 percent / KOH / various solvent(s) / 12 h / Heating 2: 1.) triethylamine, chlorocarbonic acid ethyl ester, 2.) NaHCO3 / 1.) acetone, from 0 deg C, 30 min, to RT, 2 h, 2.) acetone, water, 4 h View Scheme
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Akopyan, S. G.; Grigoryan, M. M.; Ter-Zakharyan, Yu. Z.; et al.
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 2 p. 169 - 173
Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 2 p. 54 - 56
反应条件
1: 60.4 percent / KOH / various solvent(s) / 12 h / Heating 2: 47.6 percent / SOCl2 / benzene / 8 h / Heating 3: 33.6 percent / NaHCO3 / acetone; H2O / 6 h / 0 - 20 °C View Scheme
参考文献
Mndzhoyan, Sh. L.; Kramer, M. S.; Akopyan, S. G.; Grigoryan, M. M.; Ter-Zakharyan, Yu. Z.; et al.
Pharmaceutical Chemistry Journal, 1992 , vol. 26, # 2 p. 169 - 173
Khimiko-Farmatsevticheskii Zhurnal, 1992 , vol. 26, # 2 p. 54 - 56
