1: 79 percent / pyridine / 5 h / Ambient temperature 2: 88 percent / DBU / acetone / 20 h / Ambient temperature 3: 1.) NaH / 1.) DMF, -10 deg C, 2.) DMF, -10 deg C, 1 h View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '113915', constants.ctx, '0')">N-chloro-succinimide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1696847', constants.ctx, '0')">dimethylsulfide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=-20&deg;C;&nbsp;3&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: potassium carbonate / CH₂Cl₂ <br />2: pyridinium trifluoroacetate; 1-[(3-dimethylamino)propyl]-3-ethylcarbodiimide HCl; DMSO / CH₂Cl₂ / 0 &deg;C<br /> <br /> &nbsp;