ammonia in methanol T=70°C; P=4897.34 Torr; 22 h; Sealed tubeLarge scale; Reagent/catalystTemperaturePressureTime;

1: ammonia / methanol / 22 h / 70 °C / 4897.34 Torr / |Sealed tube; |Large scale 2: hydrogenchloride / isopropyl alcohol / 4 h / 50 °C / |Large scale 3: benzotriazol-1-ol; 4-methyl-morpholine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / water; ethyl acetate; 1-methyl-pyrrolidin-2-one / 16 h / 20 - 24 °C 4: acetic acid; 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; NaMnO4 / tert-butyl methyl ether; water / 12 °C View Scheme