4-(1-吡唑基)苯甲酸甲酯合成路线 （共 9 条）
反应条件
caesium carbonate; copper(I) oxide in N,N-dimethyl-formamide T=100°C; 18 h;
参考文献
Correa, Arkaitz; Bolm, Carsten
Advanced Synthesis and Catalysis, 2007 , vol. 349, # 17-18 p. 2673 - 2676
反应条件
1: With sulfuric acid T=20°C; Reflux; 2: With sodium hydrogencarbonate in ethanol; water; ethyl acetate
参考文献
Miller, Chris P.
Patent: US2009/253758 A1, 2009 ;
Location in patent: Page/Page column 100-101 ;
反应条件
caesium carbonate; copper(II) oxide; iron (III) acetylacetonate in N,N-dimethyl-formamide T=90°C; 30 h;
参考文献
Taillefer, Marc; Xia, Ning; Ouali, Armelle
Angewandte Chemie - International Edition, 2007 , vol. 46, # 6 p. 934 - 936
反应条件
[3,2-c]pyrazole; NaH in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; dimethyl sulfoxide
参考文献
Sumitomo Pharmaceuticals Company, Limited
Patent: EP1479384 A1, 2004 ;
反应条件
sodium hydride in dimethyl sulfoxide T=100°C; 18 h;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
palladium diacetate; potassium carbonate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in acetone T=50°C; Inert atmosphereGlovebox;
参考文献
Tschaen, Brittany A.; Schmink, Jason R.; Molander, Gary A.
Organic Letters, 2013 , vol. 15, # 3 p. 500 - 503
反应条件
1: 89 percent / NaBH4, CaCl2 / tetrahydrofuran / Ambient temperature 2: 88 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 1.5 h / Ambient temperature View Scheme
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
sodium tetrahydroborate; calcium chloride in tetrahydrofuran Ambient temperature;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
1: 89 percent / NaBH4, CaCl2 / tetrahydrofuran / Ambient temperature
2: 95 percent / SOCl2 / 1.) RT, 30 min, 2.) reflux, 1.5 h
3: 68 percent / acetonitrile / 3 h / Ambient temperature
4: 93 percent / aq. HCl / 48 h / Heating
View Scheme
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
