4-(1,2,4-三唑-1-基)苯甲酸乙酯合成路线 （共 7 条）
反应条件
sodium hydride in dimethyl sulfoxide T=100°C; 18 h;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
potassium carbonate in N,N-dimethyl-formamide T=100°C; 3 h;
参考文献
US6359134 B1, ;
Referential example 17 ;
US 6359134 B1
反应条件
1: 77 percent / NaBH4, CaCl2 / tetrahydrofuran / Ambient temperature 2: 49 percent / pyridinium chlorochromate (PCC) / CH2Cl2 / 1.5 h / Ambient temperature View Scheme
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
sodium tetrahydroborate; calcium chloride in tetrahydrofuran Ambient temperature;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
1: 77 percent / NaBH4, CaCl2 / tetrahydrofuran / Ambient temperature 2: 90 percent / SOCl2 / 1.) RT, 30 min, 2.) reflux, 24 h View Scheme
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
1: With sodium hydroxide in tetrahydrofuran; ethanol T=20°C; 2 h; 2: With hydrogenchloride in water
参考文献
Takeda Chemical Industries, Ltd.
Patent: US6359134 B1, 2002 ;
Location in patent: Referential example 17 ;
US 6359134 B1
反应条件
hydrazine hydrate in ethanol
T=100°C; 3 h;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
