1-(4-羟甲基苯基)吡唑合成路线 （共 4 条）
反应条件
sodium tetrahydroborate; calcium chloride in tetrahydrofuran Ambient temperature;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
1: 74 percent / NaH / dimethylsulfoxide / 18 h / 100 °C 2: 89 percent / NaBH4, CaCl2 / tetrahydrofuran / Ambient temperature View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 27, # 3 p. 219 - 228
反应条件
pyridinium chlorochromate in dichloromethane 1.5 h; Ambient temperature;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
1: 95 percent / SOCl2 / 1.) RT, 30 min, 2.) reflux, 1.5 h
2: 68 percent / acetonitrile / 3 h / Ambient temperature
3: 93 percent / aq. HCl / 48 h / Heating
View Scheme
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
