1-[4-(氯甲基)苯基]-1H-1,2,4-噻唑合成路线 （共 3 条）
反应条件
thionyl chloride 1.) RT, 30 min, 2.) reflux, 24 h;
参考文献
Artico; Silvestri; Stefancich; Avigliano; Di Giulio; Maccarrone; Agostinelli; Mondovi; Morpurgo
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 3 p. 219 - 228
反应条件
1: 48 percent / NaH / dimethylsulfoxide / 18 h / 100 °C 2: 77 percent / NaBH4, CaCl2 / tetrahydrofuran / Ambient temperature 3: 90 percent / SOCl2 / 1.) RT, 30 min, 2.) reflux, 24 h View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 27, # 3 p. 219 - 228
反应条件
1: 77 percent / NaBH4, CaCl2 / tetrahydrofuran / Ambient temperature 2: 90 percent / SOCl2 / 1.) RT, 30 min, 2.) reflux, 24 h View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 27, # 3 p. 219 - 228
