2,7-双(氯甲基)-3,8-二氢-5,10-二羟基-3,8-二甲基嘧啶并[4,5-g]喹唑啉-4,9-二酮合成路线 (共 11 条)
反应条件
1: 78 percent / pyridine / dimethylformamide / 4 h / Ambient temperature 2: 67 percent / conc. sulfuric acid / acetic acid / 5 h / 100 °C 3: 72 percent / BBr3 / benzene / 7 h / Heating 4: 85 percent / LiCl, (dimethylamino)pyridine, methanesulfonyl chloride / dimethylformamide / 6 h / Ambient temperature View Scheme
参考文献
Lemus; Skibo
Journal of Organic Chemistry, 1992 , vol. 57, # 21 p. 5649 - 5660