5,6,7,8-四氢-[1]-苯并噻吩[2,3-d]嘧啶-4(1h)-酮合成路线 （共 20 条）
反应条件
1: POCl3 2: N2H4*H2O / ethanol View Scheme
参考文献
Ram
Archiv der Pharmazie, 1979 , vol. 312, # 1 p. 19 - 25
反应条件
pyridine; tetraphosphorus decasulfide 2 h; Reflux;
参考文献
Al-Taisan, Khulud M.; Al-Hazimi, Hassan M. A.; Al-Shihry, Shar S.
Molecules, 2010 , vol. 15, # 6 p. 3932 - 3957
反应条件
1: PhNMe2, POCl3
2: ethanol
View Scheme
参考文献
Ram
Archiv der Pharmazie, 1979 , vol. 312, # 1 p. 19 - 25
反应条件
sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate; sodium carbonate in benzene
T=60°C; 6 h;
参考文献
Bohm; Pech; Schneider
Pharmazie, 1983 , vol. 38, # 2 p. 135 - 136
反应条件
sodium hydroxide
2 h;
参考文献
Ram; Pandey; Vlietinck
Journal of Heterocyclic Chemistry, 1981 , vol. 18, # 7 p. 1277 - 1280
反应条件
1: trichlorophosphate / 3 h / 90 °C / Inert atmosphere
2: ammonium hydroxide / 1,4-dioxane; water / 1 h / 100 °C / Microwave irradiation
View Scheme
参考文献
Sleebs, Brad E.; Nikolakopoulos, George; Street, Ian P.; Falk, Hendrik; Baell, Jonathan B.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5992 - 5994
反应条件
1: PhNMe2, POCl3
2: ethanol
View Scheme
参考文献
Ram
Archiv der Pharmazie, 1979 , vol. 312, # 1 p. 19 - 25
反应条件
potassium carbonate in acetone
T=55°C; 48 h;
参考文献
Lou, Jiangping; Liu, Zhen; Li, Yan; Zhou, Mi; Zhang, Zhengxi; Zheng, Shu; Wang, Renxiao; Li, Jian
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 22 p. 6662 - 6666
反应条件
potassium carbonate in acetone
24 h; Heating;
参考文献
Ghorab, M. M.; Hamide, S. G. Abdel
Phosphorus, Sulfur and Silicon and the Related Elements, 1995 , vol. 106, # 1-4 p. 9 - 20
反应条件
1: POCl3
2: N2H4*H2O / ethanol
View Scheme
参考文献
Ram
Archiv der Pharmazie, 1979 , vol. 312, # 1 p. 19 - 25
