trichlorophosphate in chloroform; N,N-dimethyl-formamide 24 h;

1: 73 percent / aq. Ca(OH)2 / ethanol / 36 h / Ambient temperature 2: 68 percent / POCl3 / CHCl3; dimethylformamide / 24 h View Scheme

1: 1.) n-BuLi / 1.) THF, n-hexane, from -70 to 5 deg C, 2.) THF, n-hexane, -65 deg C, 1 h 2: 73 percent / aq. Ca(OH)2 / ethanol / 36 h / Ambient temperature 3: 68 percent / POCl3 / CHCl3; dimethylformamide / 24 h View Scheme

ammonium hydroxide in N,N-dimethyl-formamide 36 h; Ambient temperature;

1: 85percent N2H4*H2O / 14 h / Heating 2: H2O / Raney Ni / 4 h / Heating View Scheme