(2-噻吩基甲基)丙二酸单乙酯合成路线 （共 7 条）
反应条件
potassium hydroxide in ethanol 48 h; Ambient temperature;
参考文献
Keenan, Richard M.; Weinstock, Joseph; Finkelstein, Joseph A.; Franz, Robert G.; Gaitanopoulos, Dimitri E.; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 13 p. 1880 - 1892
反应条件
1: 93 percent / piperidine, benzoic acid / cyclohexane / 20 h / Heating 2: 92 percent / NaBH4 / ethanol / 0 °C 3: 91 percent / 87.5percent KOH / ethanol / 48 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 13 p. 1880 - 1892
反应条件
1: 92 percent / NaBH4 / ethanol / 0 °C 2: 91 percent / 87.5percent KOH / ethanol / 48 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 13 p. 1880 - 1892
反应条件
1: 93 percent / piperidine, benzoic acid / cyclohexane / 20 h / Heating 2: 92 percent / NaBH4 / ethanol / 0 °C 3: 91 percent / 87.5percent KOH / ethanol / 48 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 13 p. 1880 - 1892
反应条件
piperidine; propionic acid in cyclohexane T=25 - 35°C; 17 h; Heating / reflux;
参考文献
MATRIX LABORATORIES LIMITED; LAHIRI, Saswata; KOILKONDA, Purandhar; ACHANTA, Nageswara, Rao; RAPOLU, Sreedhar; ACHAR, Mouneshwar; LANDE, Hemaraj; SHARMA, Jitendra; DACHAPALLI, Venkanna; DATTA, Debashish
Patent: WO2010/23688 A2, 2010 ;
Location in patent: Page/Page column 6-7 ;
反应条件
1: With piperidine; hydrogenchloride in di-isopropyl ether; water T=40 - 55°C; P=760.051 Torr; Heating / reflux; 2: With water; sodium hydroxide in methanol 3 h; Heating / reflux; 3: With hydrogenchloride in methanol; water T=35 - 40°C; pH=5.0 - 5.2;
参考文献
NEULAND LABORATORIES LTD
Patent: WO2009/84028 A2, 2009 ;
Location in patent: Page/Page column 7; 11-12 ;
反应条件
1.1: piperidine; propionic acid / toluene; hexane / 25 - 70 °C / Reflux 2.1: sodium hydroxide / ethanol; water / 4 - 5 h / 25 - 60 °C 2.2: pH 5 View Scheme
参考文献
HETERO RESEARCH FOUNDATION
Patent: US2011/54186 A1, 2011 ;
