4-苄氧基-3-硝基苯乙酮合成路线 （共 14 条）
反应条件
1: 1-[4-hydroxy-3-nitrophenyl]ethanone With potassium carbonate in water; acetone T=20°C; 2: benzyl chloride With potassium iodide in water; acetone 17 h; Reflux;
参考文献
Shan, Wen-Jun; Huang, Ling; Zhou, Qi; Jiang, Huai-Lei; Luo, Zong-Hua; Lai, Ke-Fang; Li, Xing-Shu
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1523 - 1526
反应条件
1: 1-[4-hydroxy-3-nitrophenyl]ethanone With N-ethyl-N,N-diisopropylamine in acetonitrile T=20°C; 2: benzyl bromide in acetonitrile T=20°C; 3 h; Reflux;
参考文献
De Koning, Pieter D.; Gladwell, Iain R.; Moses, Ian B.; Panesar, Maninder S.; Pettman, Alan J.; Thomson, Nicholas M.
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1247 - 1255
反应条件
1: HNO3 / acetic acid / 0 °C 2: TBAI, K2CO3 / acetone View Scheme
参考文献
Acta Crystallographica, Section C: Crystal Structure Communications, , vol. 50, # 8 p. 1294 - 1295
参考文献
Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft, , vol. 296, p. 107 - 120
参考文献
WO2005/35495 A2, ;
Page/Page column 92 ;
参考文献
US5770615 A1, ;
US 5770615 A
反应条件
1: platinum(IV) oxide; hydrogen / tetrahydrofuran; toluene / 24 h / 25 °C / 772.58 Torr 2: pyridine / acetonitrile / 1 h / 25 °C View Scheme
参考文献
De Koning, Pieter D.; Gladwell, Iain R.; Moses, Ian B.; Panesar, Maninder S.; Pettman, Alan J.; Thomson, Nicholas M.
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1247 - 1255
反应条件
1: Br2 / CHCl3 2: 1.) NaBH4 2.) NaOH / 1.) MeOH View Scheme
参考文献
Mohan, K. Chandra; Ravikumar, K.; Vittal, T. V. S. K.; Gido, C. K.
Acta Crystallographica, Section C: Crystal Structure Communications, 1994 , vol. 50, # 8 p. 1294 - 1295
反应条件
phenyltrimethylammonium tribromide in methanol; dichloromethane T=20°C;
参考文献
Givens, Richard S.; Stensrud, Kenneth; Conrad, Peter G.; Yousef, Abraham L.; Perera, Chamani; Senadheera, Sanjeewa N.; Heger, Dominik; Wirz, Jakob
Canadian Journal of Chemistry, 2011 , vol. 89, # 3 p. 364 - 384
反应条件
1: 82 percent / Br2 / CHCl3 / 25 °C 2: 87 percent / BH3*THF / tetrahydrofuran / -20 °C 3: lipase PS Celite-immobilized / various solvent(s) / 72 h / 37 °C 4: K2CO3 / methanol / 2.5 h / 20 °C View Scheme
参考文献
Campos, Francisco; Bosch, M. Pilar; Guerrero, Angel
Tetrahedron Asymmetry, 2000 , vol. 11, # 13 p. 2705 - 2717
