N-(2-(苄氧基)-5-(2-溴乙酰基)苯基)甲烷磺酰胺合成路线 （共 4 条）
反应条件
tetra-n-butylammonium tribromide in tetrahydrofuran; methanol
T=25°C; 1.75 h;
参考文献
De Koning, Pieter D.; Gladwell, Iain R.; Moses, Ian B.; Panesar, Maninder S.; Pettman, Alan J.; Thomson, Nicholas M.
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1247 - 1255
反应条件
1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C
1.2: 3 h / 20 °C / Reflux
2.1: platinum(IV) oxide; hydrogen / tetrahydrofuran; toluene / 24 h / 25 °C / 772.58 Torr
3.1: pyridine / acetonitrile / 1 h / 25 °C
4.1: tetra-n-butylammonium tribromide / tetrahydrofuran; methanol / 1.75 h / 25 °C
View Scheme
参考文献
De Koning, Pieter D.; Gladwell, Iain R.; Moses, Ian B.; Panesar, Maninder S.; Pettman, Alan J.; Thomson, Nicholas M.
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1247 - 1255
反应条件
1: platinum(IV) oxide; hydrogen / tetrahydrofuran; toluene / 24 h / 25 °C / 772.58 Torr
2: pyridine / acetonitrile / 1 h / 25 °C
3: tetra-n-butylammonium tribromide / tetrahydrofuran; methanol / 1.75 h / 25 °C
View Scheme
参考文献
De Koning, Pieter D.; Gladwell, Iain R.; Moses, Ian B.; Panesar, Maninder S.; Pettman, Alan J.; Thomson, Nicholas M.
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1247 - 1255
反应条件
1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C
1.2: 3 h / 20 °C / Reflux
2.1: platinum(IV) oxide; hydrogen / tetrahydrofuran; toluene / 24 h / 25 °C / 772.58 Torr
3.1: pyridine / acetonitrile / 1 h / 25 °C
4.1: tetra-n-butylammonium tribromide / tetrahydrofuran; methanol / 1.75 h / 25 °C
View Scheme
参考文献
De Koning, Pieter D.; Gladwell, Iain R.; Moses, Ian B.; Panesar, Maninder S.; Pettman, Alan J.; Thomson, Nicholas M.
Organic Process Research and Development, 2011 , vol. 15, # 6 p. 1247 - 1255
