乙基4,4,4-三氟-2-甲基丁酸酯合成路线 （共 4 条）
反应条件
n-butyllithium; diisopropylamine in tetrahydrofuran; dichloromethane
参考文献
Imperial Chemical Industries PLC
Patent: US5286740 A1, 1994 ;
反应条件
lithium hydroxide monohydrate in tetrahydrofuran; methanol; water
参考文献
Imperial Chemical Industries PLC
Patent: US5286740 A1, 1994 ;
反应条件
lithium diisopropyl amide
1.) THF, -78 deg C, 2.) THF, -30 deg C; Multistep reaction;
参考文献
Jacobs, Robert T.; Bernstein, Peter R.; Cronk, Laura A.; Vacek, Edward P.; Newcomb, Lisa F.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1282 - 1297
反应条件
1: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 2.) THF, -30 deg C
2: lithium hydroxide monohydrate / methanol; tetrahydrofuran; H2O
View Scheme
参考文献
Jacobs, Robert T.; Bernstein, Peter R.; Cronk, Laura A.; Vacek, Edward P.; Newcomb, Lisa F.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 9 p. 1282 - 1297
