1,3-二溴-5-氟苯合成路线

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American Home Products Corporation; Ligand Pharmaceuticals, Inc.
Patent: US6355648 B1, 2002 ;
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US 6355648 B1

1435-51-41,3-二溴-5-氟苯

179898-34-13-溴-5-氟苯腈

参考文献

GLAXO GROUP LIMITED
Patent: WO2009/100169 A1, 2009 ;
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WO 2009/100169 A1

1435-51-41,3-二溴-5-氟苯

179898-34-13-溴-5-氟苯腈

参考文献

Ligand Pharmaceuticals Incorporated
Patent: US5693646 A1, 1997 ;
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179898-34-13-溴-5-氟苯腈

参考文献

Glaxo Group Limited
Patent: US2009/197871 A1, 2009 ;
Location in patent: Page/Page column 48-49 ;
US 20090197871 A1

1435-51-41,3-二溴-5-氟苯+

544-92-3氰化亚铜

179898-34-13-溴-5-氟苯腈

参考文献

MERCK and CO., INC.
Patent: WO2006/115895 A2, 2006 ;
Location in patent: Page/Page column 9 ;

1435-51-41,3-二溴-5-氟苯

887266-90-23-溴-5-氟苯甲酰氯

参考文献

Raboisson, Patrick; Breitholtz-Emanuelsson, Anna; Dahlloef, Henrik; Kers, Annika; Minidis, Alexander B. E.; Nordmark, Anna; Stroem, Peter; Terelius, Ylva; Wensbo, David; Edwards, Louise; Isaac, Methvin; Jarvie, Keith; Slassi, Abdelmalik; Wilson, Julie M.; Xin, Tao; Heaton, William L.; Sheehan, Susan M.; McLeod, Donald A.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 22 p. 6974 - 6979,6

1435-51-41,3-二溴-5-氟苯+

105-13-5茴香醇

915410-93-4

参考文献

F. HOFFMANN-LA ROCHE AG
Patent: WO2008/145563 A2, 2008 ;
Location in patent: Page/Page column 19-20 ;

1435-51-41,3-二溴-5-氟苯

507269-27-43-氟-5-[5-(吡啶-2-基)-2H-四唑-2-基]苯甲腈

参考文献

Poon, Steve F.; Eastman, Brian W.; Chapman, Deborah F.; Chung, Janice; Cramer, Merryl; Holtz, Gregory; Cosford, Nicholas D.P.; Smith, Nicholas D.
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 22 p. 5477 - 5480

108-22-5乙酸异丙烯酯+

1435-51-41,3-二溴-5-氟苯

605681-34-3

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MERCK and CO., INC.
Patent: WO2005/9479 A1, 2005 ;
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WO 2005/009479 A1