N-(t-叔丁氧羰基)-3-苯基异丝氨酸乙酯合成路线 （共 16 条）
反应条件
sodium hydrogencarbonate in dichloromethane T=20°C;
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate 69 h;
参考文献
Cabon; Buisson; Larcheveque; Azerad
Tetrahedron Asymmetry, 1995 , vol. 6, # 9 p. 2211 - 2218
反应条件
1: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 2: 76 percent / NaHCO3 / CH2Cl2 / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 1.) Et3N, Bu2BOTf / 1.) CH2Cl2, -70 to 20 deg C, 2 h, 2.) -78 to 0 deg C, 1 h 2: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C 3: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C 4: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 5: 76 percent / NaHCO3 / CH2Cl2 / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C 2: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 3: 76 percent / NaHCO3 / CH2Cl2 / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C 2: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C 3: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr 4: 76 percent / NaHCO3 / CH2Cl2 / 20 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
triethylamine in dichloromethane T=20°C; optical yield given as percent ee;
参考文献
Devi, Joymati; Saikia, Partha Pratim; Barua, Nabin C.
Letters in Organic Chemistry, 2009 , vol. 6, # 8 p. 616 - 618
反应条件
1.1: sulfuric acid / 45 - 55 °C 1.2: pH 8 - 9 2.1: dichloromethane / 0.25 h / 20 °C View Scheme
参考文献
SHILPA MEDICARE LIMITED; SHRAWAT, Vimal Kumar; PUROHIT, Prashant; RAFIUDDIN, .
Patent: WO2012/117417 A1, 2012 ;
反应条件
1: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 2: 100 percent / LiOH, H2O / ethanol / 20 °C 3: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
pyridinium p-toluenesulfonate in toluene T=80°C;
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
