5-(3-羟基苯基)戊酸乙酯合成路线 （共 14 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=2585.81 Torr;
参考文献
F. HOFFMANN-LA ROCHE AG; GILLESPIE, Paul; MICHOUD, Christophe; RUPERT, Kenneth Carey; THAKKAR, Kshitij Chhabilbhai; YI, Lin
Patent: WO2012/123467 A1, 2012 ;
Location in patent: Page/Page column 25; 26 ;
反应条件
1: 91 percent / K2CO3 / dimethylformamide / 24 h / 80 °C 2: DIBALH / CH2Cl2 / 0.5 h / -78 °C 3: 4 Angstroem molecular sieves / CH2Cl2 / 2.5 h / Ambient temperature 4: hydrogen / 1.) PtO2; 2.) Pd/C / 1.) aq. EtOH; 2.) aq. EtOH, 6 h View Scheme
参考文献
Tetrahedron, , vol. 50, # 41 p. 11945 - 11966
反应条件
1: DIBALH / CH2Cl2 / 0.5 h / -78 °C 2: 4 Angstroem molecular sieves / CH2Cl2 / 2.5 h / Ambient temperature 3: hydrogen / 1.) PtO2; 2.) Pd/C / 1.) aq. EtOH; 2.) aq. EtOH, 6 h View Scheme
参考文献
Tetrahedron, , vol. 50, # 41 p. 11945 - 11966
反应条件
1: 4 Angstroem molecular sieves / CH2Cl2 / 2.5 h / Ambient temperature 2: hydrogen / 1.) PtO2; 2.) Pd/C / 1.) aq. EtOH; 2.) aq. EtOH, 6 h View Scheme
参考文献
Tetrahedron, , vol. 50, # 41 p. 11945 - 11966
反应条件
1: 97 percent / conc. H2SO4 / 7 h / Heating 2: 98 percent / hydrogen / PtO2 / aq. ethanol / 20 h / Ambient temperature 3: 91 percent / K2CO3 / dimethylformamide / 24 h / 80 °C 4: DIBALH / CH2Cl2 / 0.5 h / -78 °C 5: 4 Angstroem molecular sieves / CH2Cl2 / 2.5 h / Ambient temperature 6: hydrogen / 1.) PtO2; 2.) Pd/C / 1.) aq. EtOH; 2.) aq. EtOH, 6 h View Scheme
参考文献
Tetrahedron, , vol. 50, # 41 p. 11945 - 11966
反应条件
1: 98 percent / hydrogen / PtO2 / aq. ethanol / 20 h / Ambient temperature 2: 91 percent / K2CO3 / dimethylformamide / 24 h / 80 °C 3: DIBALH / CH2Cl2 / 0.5 h / -78 °C 4: 4 Angstroem molecular sieves / CH2Cl2 / 2.5 h / Ambient temperature 5: hydrogen / 1.) PtO2; 2.) Pd/C / 1.) aq. EtOH; 2.) aq. EtOH, 6 h View Scheme
参考文献
Tetrahedron, , vol. 50, # 41 p. 11945 - 11966
反应条件
1: 98 percent / H2 / PtO2 / ethanol / 20 h / Ambient temperature 2: 91 percent / K2CO3 / dimethylformamide / 24 h / 80 °C 3: DIBALH / CH2Cl2 / 0.5 h / -78 °C 4: 4 Angstroem mol. sieve / CH2Cl2 / 2.5 h / Ambient temperature 5: 96 percent / H2 / PtO2, Pd/C / ethanol / 24 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 27 p. 3919 - 3922
反应条件
1: 93 percent / pyridine, piperdine / 8 h / Heating 2: 97 percent / H2SO4 / 7 h / Heating 3: 98 percent / H2 / PtO2 / ethanol / 20 h / Ambient temperature 4: 91 percent / K2CO3 / dimethylformamide / 24 h / 80 °C 5: DIBALH / CH2Cl2 / 0.5 h / -78 °C 6: 4 Angstroem mol. sieve / CH2Cl2 / 2.5 h / Ambient temperature 7: 96 percent / H2 / PtO2, Pd/C / ethanol / 24 h / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 33, # 27 p. 3919 - 3922
反应条件
1.1: potassium carbonate; tetrabutyl-ammonium chloride / palladium diacetate / N,N-dimethyl-formamide / 1 h / 70 °C 1.2: 20 °C 2.1: hydrogen / palladium 10 on activated carbon / methanol / 2585.81 Torr View Scheme
反应条件
1.1: potassium carbonate; tetrabutyl-ammonium chloride / palladium diacetate / N,N-dimethyl-formamide / 1 h / 70 °C 1.2: 20 °C 2.1: hydrogen / palladium 10 on activated carbon / methanol / 2585.81 Torr View Scheme
