methanesulfonic acid in toluene 6 h; Heating;

1.1: phosphorus pentachloride / dichloromethane / 2.18 h / -15 - 21 °C 1.2: 4 h / 20 °C 2.1: 1-methyl-pyrrolidin-2-one; ruthenium(III) chloride*(x)H2O; potassium carbonate; triphenylphosphine / 12 h / 140 °C / Inert atmosphere 3.1: methanol; sodium methylate / 9 h 4.1: trimethylsilyl bromide / acetonitrile / 4.5 h / 50 °C 5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 50 °C 6.1: pyridine / toluene / 9 h / 20 - 40 °C 7.1: 5 Pd(II)/C(eggshell); ammonium formate / water / 4.23 h / 20 - 45 °C View Scheme