3-溴-8-氯咪唑并[1,2-a]吡嗪合成路线 （共 8 条）
反应条件
N-bromosuccinmide in dichloromethane T=20°C; 2 h;
参考文献
BIOFOCUS DPI LIMITED
Patent: WO2009/24585 A2, 2009 ;
Location in patent: Page/Page column 46 ;
反应条件
bromine in acetic acid T=20°C; 73.6667 h;
参考文献
Schering Corporation
Patent: US2007/117804 A1, 2007 ;
Location in patent: Page/Page column 47 ;
US 20070117804 A1
反应条件
bromine; acetic acid T=20°C; 16 h;
参考文献
WO2010/69684 A1, ;
Page/Page column 97 ;
反应条件
in methanol; dichloromethane T=40°C; 2 h;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2004/41826 A1, 2004 ;
Location in patent: Page 26-27 ;
反应条件
ammonia in water; isopropyl alcohol T=85°C; 72 h;
参考文献
Schering Corporation
Patent: US2007/117804 A1, 2007 ;
Location in patent: Page/Page column 75 ;
US 20070117804 A1
参考文献
BioMarin IGA, Ltd.; WREN, Stephen Paul; WYNNE, Graham Michael; LECCI, Cristina; WILSON, Francis Xavier; PRICE, Paul Damien; MIDDLETON, Penny
Patent: WO2010/69684 A1, 2010 ;
Location in patent: Page/Page column 110 ;
参考文献
Belanger, David B.; Curran, Patrick J.; Hruza, Alan; Voigt, Johannes; Meng, Zhaoyang; Mandal, Amit K.; Siddiqui, M. Arshad; Basso, Andrea D.; Gray, Kimberly
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 17 p. 5170 - 5174
反应条件
in dimethyl sulfoxide
T=100°C; 16 h;
参考文献
BioMarin IGA, Ltd.; WREN, Stephen Paul; WYNNE, Graham Michael; LECCI, Cristina; WILSON, Francis Xavier; PRICE, Paul Damien; MIDDLETON, Penny
Patent: WO2010/69684 A1, 2010 ;
Location in patent: Page/Page column 97-98 ;
