3-(4-氯代丁基)-5-氰基吲哚合成路线 （共 9 条）
反应条件
chloro-trimethyl-silane; sodium cyanoborohydride in acetonitrile T=0 - 30°C;
参考文献
SYMED LABS LIMITED; MOHAN RAO, Dodda; JITHENDER, Aadepu
Patent: WO2014/6637 A2, 2014 ;
Location in patent: Page/Page column 41; 42 ;
反应条件
phosphoric acid T=65 - 75°C;
参考文献
WO2014/5134 A2, ;
Paragraph 0065 ;
反应条件
1: 73 percent / isobutyl-AlCl2 / CH2Cl2 / 15 - 30 °C 2: 26 percent / sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene / 2 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 47, # 19 p. 4684 - 4692
反应条件
1: triethylamine / toluene / 2 h / 0 - 20 °C 2: phosphoric acid / 65 - 75 °C View Scheme
反应条件
1: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; sodium hypochlorite; sodium hydrogencarbonate / toluene / 0 °C 2: triethylamine / toluene / 2 h / 0 - 20 °C 3: phosphoric acid / 65 - 75 °C View Scheme
反应条件
1: 3-(4-chloro-butyl)-5-cyanoindole With sodium iodide in N,N-dimethyl-formamide T=25 - 30°C; 0.25 h; 2: 1-(2-aminocarbonylbenzofuran-5-yl)piperazine With tetrabutylammomium bromide; sodium hydrogencarbonate in N,N-dimethyl-formamide T=110 - 115°C; 1.25 h; Reagent/catalystTemperatureTimeSolvent;
参考文献
DR.REDDYS LABORATORIES LIMITED; IQBAL, Javed; ORUGANTI, Srinivas; RAPOLU, Rajesh Kumar; PEDDY, Vishweshwar; BOGE, Rajesham; PATHIVADA, Deepika; VELAGA, Dharma Jagannadha Rao; YARRAGUNTLA, Sesha Reddy; BADDAM, Sudhakar Reddy; NAREDLA, Anitha; DONIPARTHI, Kiran Kumar; NADGOUD, Ramesh Kumar; PAGADALA, Narasimha Rao; UNNIARAN, Syam Kumar; RAMAKRISHNAN, Srividya
Patent: WO2013/168126 A1, 2013 ;
Location in patent: Page/Page column 75-78 ;
反应条件
1: K2CO3; Et3N / acetonitrile / 12 h / Heating 2: KOH / methanol / 3 h / Heating 3: 72 percent / 1-methyl-2-chloropyridinium iodide; Et2NiPr; NH3(g) / 1-methyl-pyrrolidin-2-one View Scheme
参考文献
Hu, Bin; Song, Qiao; Xu, Yungen
Organic Process Research and Development, 2012 , vol. 16, # 9 p. 1552 - 1557
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate; potassium iodide in acetonitrile T=20 - 82°C; 24 h; Reagent/catalyst;
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
反应条件
1: K2CO3; Et3N / acetonitrile / 12 h / Heating 2: KOH / methanol / 3 h / Heating View Scheme
参考文献
Heinrich, Timo; Boettcher, Henning; Gericke, Rolf; Bartoszyk, Gerd D.; Anzali, Soheila; Seyfried, Christoph A.; Greiner, Hartmut E.; Van Amsterdam, Christoph
Journal of Medicinal Chemistry, 2004 , vol. 47, # 19 p. 4684 - 4692
