(2R,3s)-3-氨基-2-羟基-3-苯基丙酸乙酯合成路线 （共 25 条）
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate P=760 Torr;
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
hydrogenchloride; hydrogen; palladium hydroxide - carbon in ethanol T=20°C; P=760 Torr; 15 h;
参考文献
Torssell, Staffan; Kienle, Marcel; Somfai, Peter
Angewandte Chemie - International Edition, 2005 , vol. 44, # 20 p. 3096 - 3099
反应条件
1: With sulfuric acid T=45 - 55°C; 2: With sodium hydrogencarbonate in dichloromethane; water pH=8 - 9;
参考文献
SHILPA MEDICARE LIMITED; SHRAWAT, Vimal Kumar; PUROHIT, Prashant; RAFIUDDIN, .
Patent: WO2012/117417 A1, 2012 ;
Location in patent: Page/Page column 9; 11 ;
反应条件
1: molecular sieves 4 Angstroem / Rh2(OAc)4 / CH2Cl2 / 10 h / 0 °C 2: 49.0 mg / para-toluenesulfonic acid / methanol; H2O / 1 h / 20 °C 3: HCl; H2 / Pd(OH)2 on C / ethanol / 15 h / 20 °C / 760 Torr View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C 2: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 81 percent / tetrahydrofuran / 0.25 h / -75 - 15 °C 2: 99 percent / NaN3, NH4Cl / ethanol / 8 h / 60 °C 3: 86 percent / H2 / 10percent Pd/C / ethyl acetate / 760 Torr View Scheme
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
1: 60 percent / NaN3, NH4Cl / aq. ethanol / Heating 2: 91 percent / pyridine / H2O 3: 35 percent / lipase P / H2O / 68 h / 25 °C / 0.1 M phosphate puffer, pH 7.00 4: NaOMe / methanol 5: H2 / 5percent Pd-C / methanol / 735.5 Torr View Scheme
参考文献
Hoenig, H.; Seufer-Wasserthal, P.; Weber, H.
Tetrahedron, 1990 , vol. 46, # 11 p. 3841 - 3850
反应条件
ammonium cerium (IV) nitrate; water in acetonitrile T=0 - 20°C;
参考文献
Jiang, Yan; Chen, Xing; Zheng, Yongsheng; Xue, Zhouyang; Shu, Chang; Yuan, Weicheng; Zhang, Xiaomei
Angewandte Chemie - International Edition, 2011 , vol. 50, # 32 p. 7304 - 7307
反应条件
1: N-((4S,5S)-4-(4-nitrophenyl)-1,3-dioxan-5-yl)picolinamide; trichlorosilane / 1,2-dichloro-ethane / 40 h / -10 °C 2: ethanol; potassium carbonate / 20 °C 3: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C View Scheme
参考文献
Jiang, Yan; Chen, Xing; Zheng, Yongsheng; Xue, Zhouyang; Shu, Chang; Yuan, Weicheng; Zhang, Xiaomei
Angewandte Chemie - International Edition, 2011 , vol. 50, # 32 p. 7304 - 7307
反应条件
1: ethanol; potassium carbonate / 20 °C 2: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C View Scheme
参考文献
Jiang, Yan; Chen, Xing; Zheng, Yongsheng; Xue, Zhouyang; Shu, Chang; Yuan, Weicheng; Zhang, Xiaomei
Angewandte Chemie - International Edition, 2011 , vol. 50, # 32 p. 7304 - 7307
