1.1: triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C 2.1: titanium tetrachloride; triethylamine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere 2.2: 20 - 40 °C / Inert atmosphere 3.1: N-((4S,5S)-4-(4-nitrophenyl)-1,3-dioxan-5-yl)picolinamide; trichlorosilane / 1,2-dichloro-ethane / 40 h / -10 °C 4.1: ethanol; potassium carbonate / 20 °C 5.1: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C View Scheme

1.1: sulfuryl dichloride / dichloromethane / 0 °C 2.1: triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C 3.1: titanium tetrachloride; triethylamine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere 3.2: 20 - 40 °C / Inert atmosphere 4.1: N-((4S,5S)-4-(4-nitrophenyl)-1,3-dioxan-5-yl)picolinamide; trichlorosilane / 1,2-dichloro-ethane / 40 h / -10 °C 5.1: ethanol; potassium carbonate / 20 °C 6.1: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C View Scheme

1.1: sodium hydride / toluene / Reflux 2.1: sulfuryl dichloride / dichloromethane / 0 °C 3.1: triethylamine / N,N-dimethyl-formamide / 20 h / 20 °C 4.1: titanium tetrachloride; triethylamine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere 4.2: 20 - 40 °C / Inert atmosphere 5.1: N-((4S,5S)-4-(4-nitrophenyl)-1,3-dioxan-5-yl)picolinamide; trichlorosilane / 1,2-dichloro-ethane / 40 h / -10 °C 6.1: ethanol; potassium carbonate / 20 °C 7.1: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C View Scheme

1.1: titanium tetrachloride; triethylamine / dichloromethane / 20 °C / Cooling with ice; Inert atmosphere 1.2: 20 - 40 °C / Inert atmosphere 2.1: N-((4S,5S)-4-(4-nitrophenyl)-1,3-dioxan-5-yl)picolinamide; trichlorosilane / 1,2-dichloro-ethane / 40 h / -10 °C 3.1: ethanol; potassium carbonate / 20 °C 4.1: ammonium cerium (IV) nitrate; water / acetonitrile / 0 - 20 °C View Scheme

sodium hydrogencarbonate in dichloromethane T=20°C;

1: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 2: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 3: 100 percent / LiOH, H2O / ethanol / 20 °C 4: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C View Scheme

1: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 2: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C View Scheme

1: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 2: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 3: 100 percent / LiOH, H2O / ethanol / 20 °C 4: 99 percent / DCC, DMAP / toluene / 2 h / 80 °C 5: 80 percent / HCOOH / 4 h / 20 °C 6: 87 percent / NaHCO3 / ethyl acetate; H2O 7: 89 percent / Zn, HOAc / methanol / 1 h / 60 °C View Scheme

1: 76 percent / NaHCO3 / CH2Cl2 / 20 °C 2: 99 percent / pyridinium paratoluenesulfonate (PTSP) / toluene / 80 °C 3: 100 percent / LiOH, H2O / ethanol / 20 °C 4: 98 percent / DCC, DMAP / toluene / 2 h / 80 °C 5: 78 percent / HCOOH / 4 h / 20 °C 6: 87 percent / NaHCO3 / tetrahydrofuran / 20 °C View Scheme

1: 10.5 mg / NaHCO3 / ethyl acetate / 0.25 h / 0 °C 2: 89 percent / LiOH*H2O / tetrahydrofuran; methanol; H2O / 1 h / 20 °C View Scheme