[(3-氨基吡啶-2-基)亚甲基氨基]硫脲合成路线 （共 9 条）
反应条件
sodium sulfide in ethanol; water
T=20°C; Zinin reduction; 18 h;
参考文献
Niu, Chuansheng; Li, Jun; Doyle, Terrence W.; Chen, Shu-Hui
Tetrahedron, 1998 , vol. 54, # 23 p. 6311 - 6318
反应条件
hydrogenchloride in ethanol; water
1.) RT, overnight, 2.) reflux, 1 h;
参考文献
Liu, Mao-Chin; Lin, Tai-Shun; Sartorelli, Alan C.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 20 p. 3672 - 3677
反应条件
1: 70 percent / selenium dioxide / dioxane / 16 h / Heating
2: 80 percent / ethanol; H2O / 6 h / 20 °C
3: 91 percent / Na2S / H2O; ethanol / 18 h / 20 °C
View Scheme
参考文献
Niu, Chuansheng; Li, Jun; Doyle, Terrence W.; Chen, Shu-Hui
Tetrahedron, 1998 , vol. 54, # 23 p. 6311 - 6318
反应条件
1: 80 percent / ethanol; H2O / 6 h / 20 °C
2: 91 percent / Na2S / H2O; ethanol / 18 h / 20 °C
View Scheme
参考文献
Niu, Chuansheng; Li, Jun; Doyle, Terrence W.; Chen, Shu-Hui
Tetrahedron, 1998 , vol. 54, # 23 p. 6311 - 6318
反应条件
hydrogenchloride in ethanol; water
Condensation; deprotection; 3 h; Heating;
参考文献
Niu, Chuansheng; Li, Jun; Doyle, Terrence W.; Chen, Shu-Hui
Tetrahedron, 1998 , vol. 54, # 23 p. 6311 - 6318
反应条件
1.1: 100 percent / triethylamine / CH2Cl2 / 0 - 5 °C
2.1: 98 percent / NaOAc; triphenylphosphine / Pd(OAc)2 / dimethylformamide / 24 h / 135 - 140 °C
3.1: O3 / methanol / 0.33 h / -78 °C
3.2: 94 percent / Me2S / methanol / 20 °C
4.1: 47 percent / conc. HCl
View Scheme
参考文献
Niu, Chuansheng; Li, Jun; Doyle, Terrence W.; Chen, Shu-Hui
Tetrahedron, 1998 , vol. 54, # 23 p. 6311 - 6318
反应条件
1: 90 percent / K2CO3 / Pd(PPh3)4 / dioxane / 48 h / Heating
2: 70 percent / selenium dioxide / dioxane / 16 h / Heating
3: 80 percent / ethanol; H2O / 6 h / 20 °C
4: 91 percent / Na2S / H2O; ethanol / 18 h / 20 °C
View Scheme
参考文献
Niu, Chuansheng; Li, Jun; Doyle, Terrence W.; Chen, Shu-Hui
Tetrahedron, 1998 , vol. 54, # 23 p. 6311 - 6318
反应条件
1: 256 mg / NaIO4 / tetrahydrofuran; H2O / 2 h / 20 °C
2: 80 percent / ethanol; H2O / 6 h / 20 °C
3: 91 percent / Na2S / H2O; ethanol / 18 h / 20 °C
View Scheme
参考文献
Niu, Chuansheng; Li, Jun; Doyle, Terrence W.; Chen, Shu-Hui
Tetrahedron, 1998 , vol. 54, # 23 p. 6311 - 6318
反应条件
hydrogenchloride
Condensation; deprotection; Title compound not separated from byproducts;
参考文献
Niu, Chuansheng; Li, Jun; Doyle, Terrence W.; Chen, Shu-Hui
Tetrahedron, 1998 , vol. 54, # 23 p. 6311 - 6318
