2-脱氧-b-l-腺苷酸合成路线 （共 11 条）
参考文献
Watanabe, Kyoichi; Choi, Woo-Baeg
Patent: US2005/90660 A1, 2005 ;
Location in patent: Page/Page column 38 ;
反应条件
pyridine; ammonium hydroxide T=50°C; 24 h;
参考文献
Spadari; Maga; Focher; Ciarrocchi; Manservigi; Arcamone; Capobianco; Carcuro; Colonna; Iotti; Garbesi
Journal of Medicinal Chemistry, 1992 , vol. 35, # 22 p. 4214 - 4220
反应条件
acetic acid in water Hydrolysis;
参考文献
Boudou
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 607 - 609
反应条件
1: 68 percent / NH2NH2*H2O / acetic acid; acetonitrile 2: DMAP / acetonitrile 3: 96 percent / [(CH3)3Si]3SiH; AIBN / dioxane 4: 72 percent / pyridine 5: 99 percent / NH3 / methanol 6: 72 percent / pyridine 7: PPh3; DEAD / tetrahydrofuran 8: NH3 / methanol 9: 80 percent / AcOH / H2O View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 607 - 609
反应条件
1: 72 percent / pyridine 2: 99 percent / NH3 / methanol 3: 72 percent / pyridine 4: PPh3; DEAD / tetrahydrofuran 5: NH3 / methanol 6: 80 percent / AcOH / H2O View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 607 - 609
反应条件
1: 72 percent / pyridine 2: PPh3; DEAD / tetrahydrofuran 3: NH3 / methanol 4: 80 percent / AcOH / H2O View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 607 - 609
反应条件
1: DMAP / acetonitrile 2: 96 percent / [(CH3)3Si]3SiH; AIBN / dioxane 3: 72 percent / pyridine 4: 99 percent / NH3 / methanol 5: 72 percent / pyridine 6: PPh3; DEAD / tetrahydrofuran 7: NH3 / methanol 8: 80 percent / AcOH / H2O View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 607 - 609
反应条件
1: 99 percent / NH3 / methanol 2: 72 percent / pyridine 3: PPh3; DEAD / tetrahydrofuran 4: NH3 / methanol 5: 80 percent / AcOH / H2O View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 607 - 609
反应条件
1: PPh3; DEAD / tetrahydrofuran 2: NH3 / methanol 3: 80 percent / AcOH / H2O View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 18, # 4-5 p. 607 - 609
反应条件
1: 1.) N,O-bis(trimethylsilyl)acetamide (BSA), 2.) (trimethylsilyl)methyl trifluoromethanesulfonate (TMS-triflate) / 1.) 1,2-dichloroethane, reflux, 30 min, 2.) 1,2-dichloroethane, reflux, 4 h 2: 69 percent / 28percent aq. ammonia, pyridine / 24 h / 50 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 22 p. 4214 - 4220
