2-(3-甲基-4-硝基苯基)乙酸合成路线 （共 7 条）
反应条件
1: With potassium hydroxide; water in methanol T=100°C; 2 h; 2: With hydrogenchloride in water
参考文献
EP1479666 A1, ;
Page 102 ;
反应条件
hydrogenchloride; water 3.5 h; Reflux;
参考文献
PFIZER INC.; CONN, Edward Lee; HEPWORTH, David; QI, Yingmei; ROCKE, Benjamin Neil; RUGGERI, Roger Benjamin; ZHANG, Yan
Patent: WO2011/145022 A1, 2011 ;
Location in patent: Page/Page column 68 ;
反应条件
sodium thiosulfate; silver(l) oxide in 1,4-dioxane T=75 - 80°C; 3 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 13 p. 2418 - 2426
反应条件
hydrogenchloride; acetic acid 6 h; Heating; Yield given;
参考文献
European Journal of Medicinal Chemistry, , vol. 31, # 2 p. 133 - 142
反应条件
1: diethyl ether / 3 h / Ambient temperature 2: Ag2O, aq. Na2S2O3 / dioxane / 3 h / 75 - 80 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 13 p. 2418 - 2426
反应条件
1: caesium carbonate / acetonitrile / 77 h / Reflux 2: hydrogenchloride; water / 3.5 h / Reflux View Scheme
反应条件
1: 65percent nitric acid, conc. H2SO4 / 1 h / Ambient temperature 2: aq. HCl, AcOH / 6 h / Heating View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 31, # 2 p. 133 - 142
