1: H2O / 0.08 h / Heating 2: 1.) N-methylmorpholine, 4-dimethylaminopyridine, isobutyl chloroformate, 2.) TEM / 1.) DMF, -15 deg C, 30 min, 2.) THF, water, a) -20 deg C, 1 h, b) r.t., 2 h View Scheme

4-methyl-morpholine; 4-(N,N-dimethlyamino)pyridine; isobutyl chloroformate 1.) DMF, -15 deg C, 30 min, 2.) THF, water, a) -20 deg C, 1 h, b) r.t., 2 h; Multistep reaction;