1: tetrahydrofuran / 0.75 h / -78 °C 3: 90 percent / imidazole / dimethylformamide / 3 h / 55 °C 4: 1.) (dba)3Pd2*CHCl3, TPP, Et3N, 2.) TBAF / 1.) toluene, reflux, 2 h, 2.) THF, RT, 30 h View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '742035', constants.ctx, '0')">trifluoroacetic acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />6.5&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '742035', constants.ctx, '0')">trifluoroacetic acid</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '102391', constants.ctx, '0')">tetrahydrofuran</a> <br />1.5&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 2.) imidazole / 1.) THF, from 0 deg C do RT, 2.) DMF, 55 deg C<br />2: CF₃CO₂H, H₂O / tetrahydrofuran / Ambient temperature<br /> <br /> &nbsp;