6-氯-3-甲氧基-4-吡嗪胺合成路线 （共 5 条）
反应条件
sodium hydroxide; bromine in water T=0 - 70°C; 4 h;
参考文献
WO2004/108707 A1, ;
Page 55-56 ;
WO 2004/108707 A1
反应条件
piperidine; hydrogen sulfide in methanol T=10 - 20°C; 0.5 h;
参考文献
Ple, Nelly; Turck, Alain; Couture, Karine; Queguiner, Guy
Synthesis, 1996 , # 7 p. 838 - 842
反应条件
1: 1.) Buli, 2.) TsN3 / 1.) THF, -75 deg C, 30 min, 2.) THF, -75 deg C, 2 h 2: 40 percent / piperidine, H2S / methanol / 0.5 h / 10 - 20 °C View Scheme
参考文献
Synthesis, , # 7 p. 838 - 842
反应条件
potassium hydroxide; potassium acetate; acetic acid 1.) 150-155 deg C, 4 h, 2.) reflux, 40 min; Yield given. Multistep reaction;
参考文献
Coates, William J.; McKillop, Alexander
Heterocycles, 1993 , vol. 35, # 2 p. 1313 - 1329
反应条件
acetic acid T=150 - 155°C; 4 h;
参考文献
Coates, William J.; McKillop, Alexander
Heterocycles, 1993 , vol. 35, # 2 p. 1313 - 1329
