4-甲基-2-硝基苯基硼酸合成路线 (共 2 条)
反应条件
1: 2-nitro-4-methyliodobenzene With phenyl-magnesium chloride in tetrahydrofuran T=-70 - -64°C; 0.416667 h; 2: boric acid trimethyl ester in tetrahydrofuran T=-68 - -60°C; 1 h; 3: With hydrogenchloride; water in tetrahydrofuran T=-20 - 20°C;
参考文献
TIBOTEC PHARMACEUTICALS LTD.; MEDIVIR AB
Patent: WO2007/14922 A1, 2007 ;
Location in patent: Page/Page column 125-126 ;
反应条件
1: With phenyl-magnesium chloride in tetrahydrofuran T=-60°C; 0.0833333 h; 2: With boric acid trimethyl ester in tetrahydrofuran T=-60°C; 0.5 h; 3: With hydrogenchloride in tetrahydrofuran T=-20°C;
参考文献
Collibee, Scott E.; Yu, Jiaxin
Tetrahedron Letters, 2005 , vol. 46, # 26 p. 4453 - 4455