3-(甲基氨基)丙酸叔丁酯合成路线 （共 5 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide T=-45 - -10°C; 2.5 h;
参考文献
Universite De Nantes; Chu Nantes; Institut National De La Sante Et De La Recherche Medicale (Inserm); Centre National De La Recherche Scientifique (CNRS)
Patent: US2010/311695 A1, 2010 ;
Location in patent: Page/Page column 6; 8 ;
反应条件
hydrogen; palladium on activated charcoal in methanol 48 h;
参考文献
Howard, Nigel I.; Bugg, Timothy D. H.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 14 p. 3083 - 3099
反应条件
1: 91 percent / methanol / 20 h / 20 °C 2: 84 percent / H2 / Pd/C / methanol / 48 h View Scheme
参考文献
Pfizer Inc.
Patent: US2012/165343 A1, 2012 ;
参考文献
Ogawa, Tadashi; Araki, Mamoru; Miyamae, Tetsuhisa; Okayama, Toru; Hagiwara, Masaki; Sakurada, Shinobu; Morikawa, Tadanori
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 7 p. 759 - 771
反应条件
1: 70 percent / EDC*HCl; DMAP / CH2Cl2 / 0 - 20 °C 2: aq. HCOOH / 20 °C View Scheme
参考文献
Ogawa, Tadashi; Araki, Mamoru; Miyamae, Tetsuhisa; Okayama, Toru; Hagiwara, Masaki; Sakurada, Shinobu; Morikawa, Tadanori
Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 7 p. 759 - 771
